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      Research Statement

      My urology research programmes bring together cell physiology and molecular biology disciplines to understand the complex cellular signalling systems which underpin normal bladder function and become dysregulated in bladder disease.

      We are also investigating the role of ion channels in the progression of urological cancers including bladder and prostate.

      Research Interests

      I obtained my PhD for research into ion channels on smooth muscle cells from the lower urinary tract. This generated my interest in the cellular basis of spontaneous activity in the bladder and set the focus of my independent research career which was marked by a New Investigator Award from BBSRC to study Kit-positive interstitial cells in the bladder. This work was carried out in the Centre for Biophotonics in the University of Strathclyde, Glasgow and formed the foundation for my application to the Wellcome Trust for a University Award (Senior Research Fellowship) in Queen's University Belfast. This award enabled the establishment of my research group in the Centre for Cancer Research and Cell Biology.

      As co-PI in the first European Union funded consortium to study urinary incontinence ("INComb" FP7 grant), our group is has made a decisive contribution to the basic cellular mechanisms underlying a condition that affects an estimated 60 million people in Europe and for which there are few effective therapies.

      Our current MRC-funded research on bladder toxicity as an adverse effect of radiation therapy will elucidate the molecular mechanisms driving typical lower urinary tract symptoms of urgency, urinary frequency, nocturia and voiding dysfunction that develop during treatment. This translational programme includes a clinical research trial in prostate cancer patients to identify predictive biomarkers of late radiation bladder toxicity.

      My interdisciplinary programme on ion channels and cancer exploits electrophysiology, molecular pathology, cell and molecular oncology and biomarker discovery to advance our knowledge of tumour biology.

      Other

      Key Words

      Urinary incontinence; urinary bladder; radiation therapy; smooth muscle; interstitial cells; Ca2+-signalling; electrophysiology; confocal microscopy; urothelial cancer; prostate cancer.

      Teaching

       

      Degree/ProgrammeRole/Module
      Medicine

      Lectures

      Physiological Basis of Clinical Practice

      Biomedical Science and Human Biology

      Lectures/Tutorials/Research Training

      Molecular Basis of Disease

      Clinical Biochemistry

      Research project and dissertation

      MRes in Translational Medicine

      Module coordinator

      Research project and dissertation

      USA Placement Programme

      Programme Coordinator

      Other

      Fellowships

      We are willing to host and support Fellowship applications for PhD or postdoctoral training.

      Frequent Journals

      • Journal of Physiology

        ISSNs: 0022-3751

        Additional searchable ISSN (Electronic): 1469-7793

        Wiley-Blackwell

        Scopus rating (2016): CiteScore 3.51 SJR 2.104 SNIP 1.277

        Journal

      • Journal of Urology

        ISSNs: 0022-5347

        Additional searchable ISSN (Electronic): 1527-3792

        Elsevier Inc.

        Scopus rating (2016): CiteScore 1.61 SJR 2.389 SNIP 1.904

        Journal

      • Neurourology and Urodynamics

        ISSNs: 0733-2467

        Additional searchable ISSN (Electronic): 1520-6777

        Wiley-Liss Inc.

        Scopus rating (2016): CiteScore 2.08 SJR 0.949 SNIP 1.383

        Journal

      • American Journal of Physiology - Cell Physiology

        ISSNs: 0363-6143

        Additional searchable ISSN (Electronic): 1522-1563

        American Physiological Society

        Scopus rating (2016): CiteScore 3.09 SJR 1.765 SNIP 1.054

        Journal

      • BJU International

        ISSNs: 1464-4096

        Additional searchable ISSN (Electronic): 1464-410X

        Wiley-Blackwell

        Scopus rating (2016): CiteScore 3.04 SJR 2.181 SNIP 1.582

        Journal

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