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    Research Statement

    My urology research programmes bring together cell physiology and molecular biology disciplines to understand the complex cellular signalling systems which underpin normal bladder function and become dysregulated in bladder disease.

    We are also investigating the role of ion channels in the progression of urological cancers including bladder and prostate.

    Research Interests

    I obtained my PhD for research into ion channels on smooth muscle cells from the lower urinary tract. This generated my interest in the cellular basis of spontaneous activity in the bladder and set the focus of my independent research career which was marked by a New Investigator Award from BBSRC to study Kit-positive interstitial cells in the bladder. This work was carried out in the Centre for Biophotonics in the University of Strathclyde, Glasgow and formed the foundation for my application to the Wellcome Trust for a University Award (Senior Research Fellowship) in Queen's University Belfast. This award enabled the establishment of my research group in the Centre for Cancer Research and Cell Biology.

    As co-PI in the first European Union funded consortium to study urinary incontinence ("INComb" FP7 grant), our group is has made a decisive contribution to the basic cellular mechanisms underlying a condition that affects an estimated 60 million people in Europe and for which there are few effective therapies.

    Our current MRC-funded research on bladder toxicity as an adverse effect of radiation therapy will elucidate the molecular mechanisms driving typical lower urinary tract symptoms of urgency, urinary frequency, nocturia and voiding dysfunction that develop during treatment. This translational programme includes a clinical research trial in prostate cancer patients to identify predictive biomarkers of late radiation bladder toxicity.

    My interdisciplinary programme on ion channels and cancer exploits electrophysiology, molecular pathology, cell and molecular oncology and biomarker discovery to advance our knowledge of tumour biology.

    Other

    Key Words

    Urinary incontinence; urinary bladder; radiation therapy; smooth muscle; interstitial cells; Ca2+-signalling; electrophysiology; confocal microscopy; urothelial cancer; prostate cancer.

    Teaching

     

    Degree/ProgrammeRole/Module
    Medicine

    Lectures

    Physiological Basis of Clinical Practice

    Biomedical Science and Human Biology

    Lectures/Tutorials/Research Training

    Molecular Basis of Disease

    Clinical Biochemistry

    Research project and dissertation

    MRes in Translational Medicine

    Module coordinator

    Research project and dissertation

    USA Placement Programme

    Programme Coordinator

    Other

    Fellowships

    We are willing to host and support Fellowship applications for PhD or postdoctoral training.

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    Frequent Journals

    • Journal of Physiology

      ISSNs: 0022-3751

      Additional searchable ISSN (Electronic): 1469-7793

      Wiley-Blackwell

      Scopus rating (2017): CiteScore 3.44 SJR 2.051 SNIP 1.132

      Journal

    • Journal of Urology

      ISSNs: 0022-5347

      Additional searchable ISSN (Electronic): 1527-3792

      Elsevier Inc.

      Scopus rating (2017): CiteScore 1.67 SJR 2.297 SNIP 1.875

      Journal

    • Neurourology and Urodynamics

      ISSNs: 0733-2467

      Additional searchable ISSN (Electronic): 1520-6777

      Wiley-Liss Inc.

      Scopus rating (2017): CiteScore 2.4 SJR 1.241 SNIP 1.568

      Journal

    • American Journal of Physiology - Cell Physiology

      ISSNs: 0363-6143

      Additional searchable ISSN (Electronic): 1522-1563

      American Physiological Society

      Scopus rating (2017): CiteScore 3.2 SJR 1.809 SNIP 1.003

      Journal

    • British Journal of Pharmacology

      ISSNs: 0007-1188

      Additional searchable ISSN (Electronic): 1476-5381

      Wiley-Blackwell

      Scopus rating (2017): CiteScore 5.97 SJR 2.603 SNIP 1.57

      Journal

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    ID: 19826