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      My interests are in translational research in acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) with the aim of improving diagnosis, prognosis and prediction of therapeutic responses. 

      Research Statement

      The molecular and cytogenetic abnormalities in Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndromes (MDS) are increasingly well defined and these are being implicated in stratification for diagnosis and prognosis.

      One research theme involves the integrated analysis of the molecular consequences of epigenetic therapies such as DNA methyltransferase inhibitors or histone deacetylase inhibitors tgene expression.   These analyses will guide further studies into developing rational epigenetic sensitised therapeutic combinations. 

      In addition, we have a series of studies being undertaken to identify repurposed therapies to target different sub-groups of adult and paediatric AML.  

      Alongside these, are studies introducing clinically relevant mutations using the CRISPR-Cas mechanism to produce isogenic cell lines to further understand the molecular disruption caused by the mutation.  Our recent direction of research has involved investigating the role of DNA repair in sub-cohorts of MDS and AML.

      Several studies are being undertaken in collaboration with previous members of the EU funded COST Action on translating genomic and epigenetic studies of MDS and AML (EuGESMA) with partners in 22 countries including Spain,  Denmark, Italy, Germany, Serbia and Finland.

      Current funding is from the Leukaemia & Lymphoma NI (LLNI), Cancer Research UK, Myeloma UK, Children’s Cancer and Leukaemia Group (CCLG)/Little Princess Trust, Department of Education and Learning (DEL) and with recent funding from Bloodwise, Queen's University Belfast, Cancer Research UK, and the R&D Division of the NI HSC.   The laboratory is also an associated member of the IMI2 funded HARMONY project.


      Acting Deputy Director:  Centre for Biomedical Science Education

      Associate Director for Undergraduate Teaching (CCRCB)

      Coordinator for the CCRCB Summer School Programme

      Module coordinator for Molecular Markers of Disease (BMS3104)

      Module coordinator for Pathobiology (BMS2023) and Cellular & Molecular Haematology (BMS3009)

      Teaching contributions to BMS2023, BMS 2106, BMS3009, BMS3104

      Module coordinator for SCM81821 and SCM7046 within both the MSc in Computational Biology and Bioinformatics and the MSc in Molecular Pathology

      Achievements and Distinctions

      Chair of the Northern Ireland council of the Royal College of Pathologists (2016-2019)

      Member of the Manx Health and Bioscience Advisory Board (2017-2019)

      REF Advisor for the School of Health Sciences, Liverpool Hope University (2016-2018)

      Frequent Journals

      • British Journal of Haematology

        ISSNs: 0007-1048, 1365-2141

        Additional searchable ISSN (Electronic): 1365-2141


        Scopus rating (2016): CiteScore 3.55 SJR 2.09 SNIP 1.536


      • Blood

        ISSNs: 0006-4971, 1528-0020

        Additional searchable ISSN (Electronic): 1528-0020


        Scopus rating (2016): CiteScore 6.93 SJR 5.842 SNIP 2.479


      • Leukemia

        ISSNs: 0887-6924, 1476-5551

        Additional searchable ISSN (Electronic): 1476-5551


        Scopus rating (2016): CiteScore 6.47 SJR 4.929 SNIP 2.213


      • Oncotarget

        ISSNs: 1949-2553

        Impact Journals

        Scopus rating (2016): CiteScore 4.73 SJR 1.927 SNIP 1.056


      • Haematologica

        ISSNs: 0390-6078, 1592-8721

        Additional searchable ISSN (Electronic): 1592-8721


        Scopus rating (2016): CiteScore 4.1 SJR 2.811 SNIP 1.687


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      Contribution to conference papers, events and activities

      ID: 46280