Lei Wang

    Lei Wang

    Lecturer

    Phone: +44 (0)28 9097 1672

    For media contact email comms.office@qub.ac.uk
    or call +44(0)2890 973091.

    Scopus Citations 3

    1. 2019
    2. Published

      Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor

      Miao, Y., Chen, G., Xi, X., Ma, C., Wang, L., Burrows, J. F., Duan, J., Zhou, M. & Chen, T., 14 Jul 2019, In : Biomolecules. 9, 7, 13 p., 280., 280

      Research output: Contribution to journalArticle

    3. Published
    4. Published

      A Novel Kunitzin-Like Trypsin Inhibitor Isolated from Defensive Skin Secretion of Odorrana versabilis

      Dong, Y., Shi, D., Ying, Y., Xi, X., Chen, X., Wang, L., Zhou, M., Wu, Q., Ma, C. & Chen, T., 28 Jun 2019, In : Biomolecules. 9, 7, 14 p., 254., 254

      Research output: Contribution to journalArticle

    5. Published

      Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of Rana pipiens and Its Truncated Analogues

      Zhou, X., Shi, D., Zhong, R., Ye, Z., Ma, C., Zhou, M., Xi, X., Wang, L., Chen, T. & Kwok, H. F., 25 Jun 2019, In : Biomolecules. 9, 6, 15 p., 249., 249

      Research output: Contribution to journalArticle

    6. Published
    7. Published
    8. Early online date

      Cloning of a Novel Trypsin Inhibitor from the Traditional Chinese Medicine Decoction Pieces, Radix Trichosanthis

      Sang, M., Ying, Y., Wu, Q., Ma, C., Xi, X., Zhou, M., Wang, L., Bininda-Emonds, O. & Chen, T., 01 Mar 2019, In : Analytical Biochemistry.

      Research output: Contribution to journalArticle

    9. Published
    10. Early online date
    11. 2018
    12. Published

      A novel antimicrobial peptide, Ranatuerin-2PLx (R2PLx), showing therapeutic potential in inhibiting proliferation of cancer cells

      Chen, X., Zhang, L., Ma, C., Zhang, Y., Xi, X., Wang, L., Zhou, M., Burrows, J. F. & Chen, T., Dec 2018, In : Bioscience Reports. 38, 6, 11 p., BSR20180710., BSR20180710

      Research output: Contribution to journalArticle

    13. Published
    14. Published
    15. Published

      Evaluating the Bioactivity of a Novel Broad-Spectrum Antimicrobial Peptide Brevinin-1GHa from the Frog Skin Secretion of Hylarana guentheri and Its Analogues

      Chen, Q., Cheng, P., Ma, C., Xi, X., Wang, L., Zhou, M., Bian, H. & Chen, T., 13 Oct 2018, In : Toxins. 10, 10, 16 p., 413., 413

      Research output: Contribution to journalArticle

    16. Published
    17. Published
    18. Published

      Comparative Profiling of Three Atheris Snake Venoms: A. squamigera, A. nitschei and A. chlorechis

      Wang, H., Chen, X., König, E., Zhou, M., Wang, L., Chen, T. & Shaw, C., Aug 2018, In : The Protein Journal. 37, 4, p. 353-360

      Research output: Contribution to journalArticle

    19. Published
    20. Published

      Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering

      Chen, X., Zhang, L., Wu, Y., Wang, L., Ma, C., Xi, X., Bininda-Emonds, O., Shaw, C., Chen, T. & Zhou, M., 01 May 2018, In : International Journal of Biological Sciences. 14, 6, p. 599-607 9 p.

      Research output: Contribution to journalArticle

    21. Published
    22. Published

      A Bowman-Birk type chymotrypsin inhibitor peptide from the amphibian, Hylarana erythraea

      Zhang, L., Chen, X., Wu, Y., Zhou, M., Ma, C., Xi, X., Chen, T., Walker, B., Shaw, C. & Wang, L., 11 Apr 2018, In : Scientific Reports. 8, 9 p., 5851., 5851

      Research output: Contribution to journalArticle

    23. Published

      Discovery of Distinctin-Like-Peptide-PH (DLP-PH) from the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide

      Wu, D., Gao, Y., Tan, Y., Liu, Y., Wang, L., Zhou, M., Xi, X., Ma, C., Bininda-Emonds, O. R. P., Chen, T. & Shaw, C., 23 Mar 2018, In : Frontiers in Microbiology. 9, 11 p., 541., 541

      Research output: Contribution to journalArticle

    24. Early online date
    25. Published
    26. Published
    27. Published
    28. 2017
    29. Published

      Assessment of antimicrobial and wound healing effects of Brevinin-2Ta against the bacterium Klebsiella pneumoniae in dermally-wounded rats

      Liu, S., Long, Q., Xu, Y., Wang, J., Xu, Z., Wang, L., Zhou, M., Wu, Y., Chen, T. & Shaw, C., 30 Nov 2017, In : Oncotarget. 8, 67, p. 111369-111386

      Research output: Contribution to journalArticle

    30. Published
    31. Published
    32. Published
    33. Published
    34. Published
    35. Published

      Identification of a Novel Vasodilatory Octapeptide from the Skin Secretion of the African Hyperoliid Frog, Kassina senegalensis

      Du, Q., Wang, H., Ma, C., Wu, Y., Xi, X., Zhou, M., Chen, T., Shaw, C. & Wang, L., 19 Jul 2017, In : Molecules. 22, 9 p., 1215., 1215

      Research output: Contribution to journalArticle

    36. Published

      Ranatensin-HL: A Bombesin-Related Tridecapeptide from the Skin Secretion of the Broad-Folded Frog, Hylarana latouchii

      Lin, Y., Chen, T., Zhou, M., Wang, L., Su, S. & Shaw, C., 04 Jul 2017, In : Molecules. 22, 7, 1110., 1110

      Research output: Contribution to journalArticle

    37. Published

      Novel Kazal-type Protease inhibitors from the skin secretion of the Splendid leaf frog, Cruziohyla calcarifer

      Proaño Bolaños, C., Li, R., Zhou, M., Wang, L., Xi, X., Tapia, E. E., Coloma, L. A., Chen, T. & Shaw, C., Jun 2017, In : EuPA Open Proteomics. 15, p. 1-13 13 p.

      Research output: Contribution to journalArticle

    38. Published

      A Structural and Functional Analogue of a Bowman Birk-type Protease Inhibitor from Odorrana Schmackeri

      Wu, Y., Long, Q., Xu, Y., Guo, S., Chen, T., Wang, L., Zhou, M., Zhang, Y., Shaw, C. & Walker, B., Apr 2017, In : Bioscience Reports. 37, 2

      Research output: Contribution to journalArticle

    39. Early online date
    40. 2016
    41. Published

      Significant improvement of direct reprogramming efficacy of fibroblasts into progenitor endothelial cells by ETV2 and hypoxia

      Van Pham, P., Vu, N. B., Nguyen, H. T., Huynh, O. T., Truong, M. T-H., Bogoslovsky, T., Shaffer, RG., Tasev, D., Colombo, E., Asahara, T., Donndorf, P., Bai, YY., Kim, SW., Kim, J., Peters, EB., Phuc, PV., Hu, CH., Hu, CH., Schuh, A., Kalka, C. & 51 othersKawamoto, A., Suh, W., Cha, SK., Haller, C., Losordo, DW., Losordo, DW., Losordo, DW., Li, SH., She, Q., Yu, JX., Flex, A., Asahara, T., Kalka, C., Isner, JM., Yoder, MC., White, MP., Wang, L., Park, SJ., Kimbrel, EA., Lanza, R., Simonson, OE., Margariti, A., Li, J., Han, JK., Morita, R., Ginsberg, M., Shi, X., Schupp, MO., Park, C., Foja, S., Shimada, H., Yoshida, Y., Iida, K., Nahm, WK., Zhou, L., Falanga, V., Liu, F., Behrens, AN., Elcheva, I., Lindgren, AG., Veldman, MB., Lin, S., Craig, MP., Zhang, Z., Jackson, J., Minchenko, A., Hitchon, C., Steinbrech, DS., Steinbrech, DS., Lee, EY. & Rehman, J., 04 Dec 2016, Stem Cell Research & Therapy. BioMed Central, p. 104 1 p. (Stem Cell Research & Therapy; vol. 7).

      Research output: Chapter in Book/Report/Conference proceedingChapter

    42. Published
    43. Published

      A Combined Molecular Cloning and Mass Spectrometric Method to Identify, Characterize, and Design Frenatin Peptides from the Skin Secretion of Litoria infrafrenata

      Wu, D., Gao, Y., Wang, L., Xi, X., Wu, Y., Zhou, M., Zhang, Y., Ma, C., Chen, T. & Shaw, C., 26 Oct 2016, In : Molecules. 21, 11, 12 p., 1429., 1429

      Research output: Contribution to journalArticle

    44. Published

      Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer

      Proaño Bolaños, C., Zhou, M., Wang, L., Luis, C., Chen, T. & Shaw, C., 02 Sep 2016, In : Journal of proteomics. 146, p. 1-13 13 p.

      Research output: Contribution to journalArticle

    45. Published
    46. Published

      Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs

      Chen, X., Wang, H., Chen, Y., Wang, L., Zhou, M., Chen, T. & Shaw, C., 19 Aug 2016, In : Biochemical and Biophysical Research Communications. 477, 2, p. 302-9 8 p.

      Research output: Contribution to journalArticle

    47. Published
    48. Published

      Identification of Miscellaneous Peptides from the Skin Secretion of the European Edible Frog, Pelophylax kl. Esculentus

      Chen, X., Wang, H., Wang, L., Zhou, M., Chen, T. & Shaw, C., Aug 2016, In : The Protein Journal. 35, 4, p. 291-299 9 p.

      Research output: Contribution to journalArticle

    49. Published

      Baltikinin: A New Myotropic Tryptophyllin-3 Peptide Isolated from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea

      Shi, D., Xi, X., Wang, L., Gao, Y., Ma, C., Chen, H., Zhou, M., Chen, T. & Shaw, C., 08 Jul 2016, In : Toxins. 8, 7, 10 p., 213., 213

      Research output: Contribution to journalArticle

    50. Published
    51. Published

      Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor

      Shi, D., Hou, X., Wang, L., Gao, Y., Wu, D., Xi, X., Zhou, M., Kwok, H. F., Duan, J., Chen, T. & Shaw, C., 12 May 2016, In : Toxins. 8, 16 p., 144., 144

      Research output: Contribution to journalArticle

    52. Published
    53. Published
    54. Published
    55. 2015
    56. Published
    57. Published

      Abnormal alterations in the Ca2+/CaV1.2/calmodulin/caMKII signaling pathway in a tremor rat model and in cultured hippocampal neurons exposed to Mg2+-free solution

      Lv, X., Guo, F., Xu, X., Chen, Z., Sun, X., Min, D., Cao, Y., Shi, X., Wang, L., Chen, T., Shaw, C., Gao, H., Hao, L. & Cai, J., Nov 2015, In : Molecular Medicine Reports. 12, 5, p. 6663-6671

      Research output: Contribution to journalArticle

    58. Published

      De novo sequencing of two novel peptides homologous to calcitonin-like peptides, from skin secretion of the Chinese Frog, Odorrana schmackeri

      Evaristo, G. P. C., Pinkse, M. W. H., Chen, T., Wang, L., Mohammed, S., Heck, A. J. R., Mathes, I., Lottspeich, F., Shaw, C., Albar, J. P. & Verhaert, P. D. E. M., Sep 2015, In : EuPA Open Proteomics. 8, p. 157-166 10 p.

      Research output: Contribution to journalArticle

    59. Published
    60. Published
    61. Published
    62. 2014
    63. Published
    64. Published
    65. Published

      Ornithokinin (avian bradykinin) from the skin of the Chinese bamboo odorous frog, Odorrana versabilis

      Lyu, P., Ge, L., Wang, L., Guo, X., Zhang, H., Li, Y., Zhou, Y., Zhou, M., Chen, T. & Shaw, C., Aug 2014, In : Journal of peptide science. 20, 8, p. 618-624 7 p.

      Research output: Contribution to journalArticle

    66. Published

      Balteatide: A Novel Antimicrobial Decapeptide from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea

      Ge, L., Chen, X., Ma, C., Zhou, M., Xi, X., Wang, L., Ding, A., Duan, J., Chen, T. & Shaw, C., 26 Jun 2014, In : The Scientific World Journal. 2014, 8 p., 176214., 176214

      Research output: Contribution to journalArticle

    67. Published
    68. Published
    69. Published

      Hylaranins: prototypes of a new class of amphibian antimicrobial peptide from the skin secretion of the oriental broad-folded frog, Hylarana latouchii

      Lin, Y., Hu, N., Lyu, P., Ma, J., Wang, L., Zhou, M., Guo, S., Chen, T. & Shaw, C., Apr 2014, In : Amino Acids. 46, 4, p. 901-909 9 p.

      Research output: Contribution to journalArticle

    70. Published

      Bradykinin-related peptides (BRPs) from skin secretions of three genera of phyllomedusine leaf frogs and their comparative pharmacological effects on mammalian smooth muscles

      Jiang, Y., Xi, X., Ge, L., Yang, N., Hou, X., Ma, J., Ma, C., Wu, Y., Guo, X., Li, R., Zhou, M., Wang, L., Chen, T. & Shaw, C., Feb 2014, In : Peptides. 52, p. 122-133 12 p.

      Research output: Contribution to journalArticle

    71. Published

      AcT-2: A Novel Myotropic and Antimicrobial Type 2 Tryptophyllin from the Skin Secretion of the Central American Red-Eyed Leaf Frog, Agalychnis callidryas

      Ge, L., Lyu, P., Zhou, M., Zhang, H., Wan, Y., Li, B., Li, R., Wang, L., Chen, T. & Shaw, C., 2014, In : The Scientific World Journal. 2014, 7 p., 158546., 158546

      Research output: Contribution to journalArticle

    72. Published

      Feleucins: Novel Bombinin Precursor-Encoded Nonapeptide Amides from the Skin Secretion of Bombina variegata

      Bai, B., Hou, X., Wang, L., Ge, L., Luo, Y., Ma, C., Zhou, M., Duan, J., Chen, T. & Shaw, C., 2014, In : BioMed Research International. 2014, 8 p., 671362., 671362

      Research output: Contribution to journalArticle

    73. 2013
    74. Published

      Ranachensinin: A Novel Aliphatic Tachykinin from the Skin Secretion of the Chinese Brown Frog, Rana chensinensis

      Wu, Y., Li, R., Ma, J., Zhou, M., Wang, L., McClure, T. I., Cai, J., Chen, T. & Shaw, C., Nov 2013, In : Protein and Peptide Letters. 20, 11, p. 1217-1224

      Research output: Contribution to journalArticle

    75. Published
    76. Published
    77. Published
    78. Published
    79. Published

      Medusins: a new class of antimicrobial peptides from the skin secretions of phyllomedusine frogs

      Xi, X., Li, R., Jiang, Y., Lin, Y., Wu, Y., Zhou, M., Xu, J., Wang, L., Chen, T. & Shaw, C., Jun 2013, In : Biochimie. 95, 6, p. 1288-1296

      Research output: Contribution to journalArticle

    80. Published

      Parallel Peptidome and Transcriptome Analyses of Amphibian Skin Secretions Using Archived Frozen Acid-Solvated Samples

      Bai, B., Zhang, Y., Wang, H., Zhou, M., Yu, Y., Ding, S., Chen, T., Wang, L. & Shaw, C., Jun 2013, In : Molecular biotechnology. 54, 2, p. 187-197

      Research output: Contribution to journalArticle

    81. Published

      Senegalin: a novel antimicrobial/myotropic hexadecapeptide from the skin secretion of the African running frog, Kassina senegalensis

      Wang, H., Li, R., Xi, X., Meng, T., Zhou, M., Wang, L., Zhang, Y., Chen, T. & Shaw, C., May 2013, In : Amino Acids. 44, 5, p. 1347-1355

      Research output: Contribution to journalArticle

    82. Published

      The alterations of Ca2+/Calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia

      Min, D., Guo, F., Zhu, S., Xu, X., Mao, X., Cao, Y., Lv, X., Gao, Q., Wang, L., Chen, T., Shaw, C., Hao, L. & Cai, J., 22 Mar 2013, In : Neuroscience Letters. 538, p. 60-65 6 p.

      Research output: Contribution to journalArticle

    83. Published

      Vasorelaxin: A Novel Arterial Smooth Muscle-Relaxing Eicosapeptide from the Skin Secretion of the Chinese Piebald Odorous Frog (Odorrana schmackeri)

      Wu, Y., Wang, L., Lin, C., Lin, Y., Zhou, M., Chen, L., Connolly, B., Zhang, Y., Chen, T. & Shaw, C., 06 Feb 2013, In : PLoS One. 8, 2, e55739., e55739

      Research output: Contribution to journalArticle

    84. Published

      The chains of the heterodimeric amphibian skin antimicrobial peptide, distinctin, are encoded by separate messenger RNAs

      Evaristo, G., Pinkse, M., Wang, L., Zhou, M., Wu, Y., Wang, H., Chen, T., Shaw, C. & Verhaert, P., 14 Jan 2013, In : Journal of proteomics. 78, p. 245-253 9 p.

      Research output: Contribution to journalArticle

    85. Published

      Abnormal changes in voltage-gated sodium channels NaV1.1, NaV1.2, NaV1.3, NaV1.6 and in Calmodulin/calmodulin-dependent protein kinase II, within the brains of spontaneously epileptic rats and tremor rats

      Xu, X., Guo, F., Lv, X., Feng, R., Min, D., Ma, L., Liu, Y., Zhao, J., Wang, L., Shaw, C., Chen, T., Hao, L. & Cai, J., 2013, In : Brian Research Bulletin. 96, p. 1-9

      Research output: Contribution to journalArticle

    86. Published

      The up-regulation of voltage-gated sodium channels subtypes coincides with an increased sodium current in hippocampal neuronal culture model

      Guo, F., Xu, X., Cai, J., Hu, H., Sun, W., He, G., Shao, D., Wang, L., Chen, T., Shaw, C., Zhu, T. & Hao, L., 2013, In : Neurochemistry International. 62, 3, p. 287-295 9 p.

      Research output: Contribution to journalArticle

    87. 2012
    88. Published
    89. Published
    90. Published

      A novel Kazal-type trypsin inhibitor from the skin secretion of the Central American red-eyed leaf frog, Agalychnis callidryas.

      Li, R., Wang, H., Jiang, Y., Yu, Y., Wang, L., Zhou, M., Zhang, Y., Chen, T. & Shaw, C., Jun 2012, In : Biochimie. 94, 6, p. 1376-1381 6 p.

      Research output: Contribution to journalArticle

    91. Published
    92. Helokinestatin-7 peptides from the venoms of Heloderma lizards

      Ma, C., Wang, H., Wu, Y., Zhou, M., Lowe, G., Wang, L., Zhang, Y., Chen, T. & Shaw, C., Jun 2012, In : Peptides. 35, 2, p. 300-305 6 p.

      Research output: Contribution to journalArticle

    93. Published

      Functional peptidomics of amphibian skin secretion: A novel Kunitz-type chymotrypsin inhibitor from the African hyperoliid frog, Kassina senegalensis

      Wang, H., Wang, L., Zhou, M., Yang, M., Ma, C., Chen, T., Zhang, Y., Zeller, M., Hornshaw, M. & Shaw, C., Mar 2012, In : Biochimie. 94, 3, p. 891-899 9 p.

      Research output: Contribution to journalArticle

    94. Published

      Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.

      Min, D., Mao, X., Wu, K., Cao, Y., Guo, F., Zhu, S., Xie, N., Wang, L., Chen, T., Shaw, C. & Cai, J., 21 Feb 2012, In : Neuroscience Letters. 510, 1, p. 29-33 5 p.

      Research output: Contribution to journalArticle

    95. Published
    96. 2011
    97. Published

      Kasstasin: A novel potent vasoconstrictor peptide from the skin secretion of the African red-legged running frog, Kassina maculata

      Li, X. H., Feng, W., Zhou, M., Ma, C., Chen, T., Zeller, M., Hornshaw, M., Wang, L. & Shaw, C., Sep 2011, In : Biochimie. 93, 9, p. 1537-1542 6 p.

      Research output: Contribution to journalArticle

    98. Published

      Limnonectins: A new class of antimicrobial peptides from the skin secretion of the Fujian large-headed frog (Limnonectes fujianensis)

      Wu, Y., Zhou, M., Wang, L., Ma, C., Chen, X., Bai, B., Chen, T. & Shaw, C., Jun 2011, In : Biochimie. 93, 6, p. 981-987 7 p.

      Research output: Contribution to journalArticle

    99. Published
    100. Published
    101. Published
    102. Published

      Kassorins: Novel innate immune system peptides from skin secretions of the African hyperoliid frogs, Kassina maculata and Kassina senegalensis

      Chen, H., Wang, L., Zeller, M., Hornshaw, M., Wu, Y., Zhou, M., Li, J., Hang, X., Cai, J., Chen, T. & Shaw, C., Jan 2011, In : Molecular Immunology. 48, 4, p. 442-451 10 p.

      Research output: Contribution to journalArticle

    103. 2010
    104. Published
    105. Published
    106. Published
    107. Published
    108. Published
    109. Published
    110. Published
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