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    Research Statement

    After graduating with a BSc (Hons) degree in Cell Biology and Molecular Genetics from University College Dublin, I completed a PhD in the Institute of Molecular Medicine, Trinity College Dublin (2001 – 2004). During this time, I developed an interest in innate host defence mechanisms in atherosclerosis and their modulation by dietary fatty acids. Following my PhD, I joined the Respiratory Research Division in the Royal College of Surgeons in Ireland as a postdoctoral scientist. In 2007, I moved to Queen’s University Belfast and I was appointed as a Lecturer in 2013.

    Since 2004, I have been actively involved in research programmes centred on host defence mechanisms and their regulation in acute and chronic lung inflammation to better understand the pathogenesis of lung diseases, such as Cystic Fibrosis (CF), Chronic Obstructive Pulmonary Disease (COPD), Alpha-1 Antitrypsin Deficiency and Acute Respiratory Distress Syndrome (ARDS). These studies investigated the status, integrity and mechanisms of action of host defence proteins (e.g. antimicrobial peptides, antiproteases, proteases), how this activity may be compromised during disease and exploited for biomarker and therapeutic potential.

    Full publication list available on Google Scholar.

     

    Research Interests

    Building on this experience, current research in our group focusses on:

    • Identifying and developing biomarkers of pulmonary infection, inflammation and damage
    • Characterising immunomodulatory properties of pulmonary proteases, antiproteases and microRNAs
    • Investigating therapeutic strategies to prevent and repair the damage in chronic lung disease
    • Developing novel peptides as anti-inflammatory and antimicrobial therapies.

     

    Achievements

    Willingness to take PhD students

    Yes

    PhD projects

    Dr Weldon is open to PhD applications from motivated and enthusiastic students in the areas of;
    - Airway inflammation and host defence
    - Repair and regeneration in the lung
    - MiRNAs as mediators of inflammation/disease and their potential therapeutic value
    - Pathogenesis of lung diseases such as Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Alpha-1-Antitrypsin Deficiency, Acute Respiratory Distress Syndrome

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    Frequent Journals

    • Thorax

      ISSNs: 0040-6376, 1468-3296

      BMJ Publishing Group

      Scopus rating (2018): CiteScore 4.63 SJR 3.697 SNIP 2.383

      Journal

    • European Respiratory Journal

      ISSNs: 0903-1936

      Additional searchable ISSN (Electronic): 1399-3003

      EUROPEAN RESPIRATORY SOC JOURNALS LTD

      Scopus rating (2018): CiteScore 4.82 SJR 3.925 SNIP 2.397

      Journal

    • Biological Chemistry

      ISSNs: 1431-6730

      Additional searchable ISSN (Electronic): 1437-4315

      Walter de Gruyter GmbH

      Scopus rating (2018): CiteScore 3.09 SJR 1.482 SNIP 0.82

      Journal

    • Biochemical society transactions

      ISSNs: 0300-5127

      Additional searchable ISSN (Electronic): 1470-8752

      Portland Press Ltd.

      Scopus rating (2018): CiteScore 4.04 SJR 2.257 SNIP 0.862

      Journal

    • PLoS One

      ISSNs: 1932-6203

      Additional searchable ISSN (Electronic): 1932-6203

      Public Library of Science

      Scopus rating (2018): CiteScore 3.02 SJR 1.1 SNIP 1.123

      Journal

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