Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

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    Chemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.



    Original languageEnglish
    Number of pages4
    Pages (from-to)13067-13070
    JournalChemical Communications
    Journal publication date10 Nov 2017
    Issue number97
    Early online date10 Nov 2017
    Publication statusPublished - 10 Nov 2017

    ID: 138054700