Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors

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    This letter describes the design, development and SAR exploration of a novel series of small legumain inhibitors. The SAR of a new small molecule legumain inhibitor chemotype was explored and found to have improved physiochemical properties compared to previously developed inhibitors within our group. However, further development of this series was found to be limited as the SAR was observed to be relatively flat.

    Original languageEnglish
    Number of pages4
    Pages (from-to)413-6
    JournalBioorganic and Medicinal Chemistry Letters
    Journal publication date15 Jan 2016
    Issue number2
    Early online date28 Nov 2015
    Publication statusPublished - 15 Jan 2016

    ID: 17939746