Guidelines on the management of acute respiratory distress syndrome

    Research output: Contribution to journalArticle


    View graph of relations

    The Faculty of Intensive Care Medicine and Intensive Care Society Guideline Development Group have used GRADE methodology to make the following recommendations for the management of adult patients with acute respiratory distress syndrome (ARDS). The British Thoracic Society supports the recommendations in this guideline. Where mechanical ventilation is required, the use of low tidal volumes (<6 ml/kg ideal body weight) and airway pressures (plateau pressure <30 cmH2O) was recommended. For patients with moderate/severe ARDS (PF ratio<20 kPa), prone positioning was recommended for at least 12 hours per day. By contrast, high frequency oscillation was not recommended and it was suggested that inhaled nitric oxide is not used. The use of a conservative fluid management strategy was suggested for all patients, whereas mechanical ventilation with high positive end-expiratory pressure and the use of the neuromuscular blocking agent cisatracurium for 48 hours was suggested for patients with ARDS with ratio of arterial oxygen partial pressure to fractional inspired oxygen (PF) ratios less than or equal to 27 and 20 kPa, respectively. Extracorporeal membrane oxygenation was suggested as an adjunct to protective mechanical ventilation for patients with very severe ARDS. In the absence of adequate evidence, research recommendations were made for the use of corticosteroids and extracorporeal carbon dioxide removal.


    • Guidelines on the management of acute respiratory distress syndrome

      Rights statement: Copyright 2019 the authors. This is an open access Creative Commons Attribution-NonCommercial License (, which permits use, distribution and reproduction for non-commercial purposes, provided the author and source are cited.

      Final published version, 974 KB, PDF-document


    Original languageEnglish
    Article numbere000420
    Number of pages27
    JournalBMJ Open Respiratory Research
    Journal publication date24 May 2019
    Issue number1
    Publication statusPublished - 24 May 2019

    ID: 175523688