Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors

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    We previously developed a tool that identified individuals who later developed esophageal adenocarcinoma (based on age, sex, body mass index, smoking status, and prior esophageal conditions) with an area under the curve of 0.80. In this study, we collected data from 329,463 individuals in the UK Biobank cohort who were tested for genetic susceptibility to esophageal adenocarcinoma (a polygenic risk score based on 18 recognized genetic variants). We found that after inclusion of this genetic information, the area under the curve for identification of individuals who developed esophageal adenocarcinoma remained at 0.80. Testing for genetic variants associated with esophageal adenocarcinoma therefore seems unlikely to improve identification of individuals at risk of esophageal adenocarcinoma.
    Original languageEnglish
    Pages (from-to)43-45
    JournalGastroenterology
    Journal publication date01 Jan 2019
    Issue number1
    Volume156
    Early online date19 Sep 2018
    DOIs
    Publication statusPublished - 01 Jan 2019

      Research areas

    • Early Detection of Cancer, oesophageal cancer, Genes

    ID: 157557225