Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications

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    In situ gels have recently received interest as ocular drug delivery vehicles because they combine the merits of easy instillation and sustained drug release. In this review, we focus on the use of poloxamers as in situ gelling systems in ocular drug delivery because of their thermoresponsive gelling behaviour, biocompatibility, and ease of sterilisation. Furthermore, the sol –gel transition temperature, mucoadhesive properties, and drug release profiles of poloxamer-based in situ gels can be finely tuned, enabling them to be used as vehicles for the delivery of small and large drug molecules to treat diseases of the anterior and posterior segments of the eye. Poloxamer- based ocular products have already found their way to the pharmaceutical market, but remain a potential arena for further investigation and commercial exploitation.

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    • Poloxamer-based in situ gelling thermo-responsive systems for ocular drug delivery applications

      Rights statement: Copyright 2019 Elsevier. This manuscript is distributed under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited

      Accepted author manuscript, 283 KB, PDF-document

      Embargo ends: 05/06/2020

    DOI

    Original languageEnglish
    JournalDrug Discovery Today
    Journal publication date06 Jun 2019
    Early online date06 Jun 2019
    DOIs
    Publication statusEarly online date - 06 Jun 2019

    ID: 171968380