Reasons to Be Nervous about Flukicide Discovery

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    The majority of anthelmintics dysregulate neuromuscular function, a fact most prominent for drugs against nematode parasites. In contrast to the strong knowledge base for nematode neurobiology, resource and tool deficits have prevented similar advances in flatworm parasites since those driven by bioimaging, immunocytochemistry, and neuropeptide biochemistry 20-30 years ago. However, recent developments are encouraging a renaissance in liver fluke neurobiology that can now support flukicide discovery. Emerging data promote neuromuscular signalling components, and especially G protein-coupled receptors (GPCRs), as next-generation targets. Here, we summarise these data and expose some of the new opportunities to accelerate progress towards GPCR-targeted flukicides for Fasciola hepatica.


    Original languageEnglish
    Number of pages13
    Pages (from-to)184-196
    JournalTrends in Parasitology
    Journal publication date01 Mar 2018
    Issue number3
    Early online date18 Dec 2017
    Publication statusPublished - 01 Mar 2018

    ID: 147185835