Selective Imaging of Damaged Bone Structure (Microcracks) Using a Targeting Supramolecular Eu(III) Complex As a Lanthanide Luminescent Contrast Agent

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    • Brian McMahon
    • Peter Mauer
    • Colin P. McCoy
    • T. Clive Lee
    • Thorfinnur Gunnlaugsson

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    The synthesis and photophysical evaluation of a new supramolecular lanthanide complex is described which was developed as a luminescent contrast agent for bone structure analysis. We show that the Eu(III) emission of this complex is not pH dependent within the physiological pH range, and that its steady state emission is not significantly modulated by a series of group I and II as well as d-metal ions, and that this agent can be successfully employed to image mechanically formed cracks (scratches) in bone samples after 4 or 24 hours, using confocal laser-scanning microscopy.


    Original languageEnglish
    Number of pages2
    Pages (from-to)17542-17543
    JournalJournal of the American Chemical Society
    Journal publication date09 Dec 2009
    Issue number48
    Early online date13 Nov 2009
    Publication statusPublished - 09 Dec 2009

    ID: 632910