The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

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    • Kader Salifou
    • Swagat Ray
    • Laure Verrier
    • Marion Aguirrebengoa
    • Didier Trouche
    • Konstantin I Panov
    • Marie Vandromme

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    The interplay between methylation and demethylation of histone lysine residues is an essential component of gene expression regulation and there is considerable interest in elucidating the roles of proteins involved. Here we report that histone demethylase KDM4A/JMJD2A, which is involved in the regulation of cell proliferation and is overexpressed in some cancers, interacts with RNA Polymerase I, associates with active ribosomal RNA genes and is required for serum-induced activation of rDNA transcription. We propose that KDM4A controls the initial stages of transition from 'poised', non-transcribed rDNA chromatin into its active form. We show that PI3K, a major signalling transducer central for cell proliferation and survival, controls cellular localization of KDM4A and consequently its association with ribosomal DNA through the SGK1 downstream kinase. We propose that the interplay between PI3K/SGK1 signalling cascade and KDM4A constitutes a mechanism by which cells adapt ribosome biogenesis level to the availability of growth factors and nutrients.

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    • The histone demethylase JMJD2A/KDM4A links ribosomal RNA transcription to nutrients and growth factors availability

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    DOI

    Original languageEnglish
    Article number10174
    Number of pages14
    JournalNature Communications
    Journal publication date05 Jan 2016
    Volume7
    DOIs
    Publication statusPublished - 05 Jan 2016

    ID: 17844484