The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity

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      Inflammatory bowel disease (IBD) is on the rise in the western world.1 The dynamic interplay between genetic susceptibility, the gut microbiome and host inflammatory reactions underlying IBD are still unclear. Shedding light onto these complex interactions in IBD, Chen et al.2 identified a key role for the negative immune regulator NLRP12 in shaping the composition of the gut microbiome and maintaining intestinal homeostasis.


      Original languageEnglish
      JournalCellular and Molecular Immunology
      Journal publication date24 Jul 2017
      Early online date24 Jul 2017
      StatePublished - 24 Jul 2017

      ID: 134044947