The Osteogenic Potential of Brown Seaweed Extracts

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    Marine drugs hold significantly more promise than their terrestrial counterparts, which could help solve the current shortfall in treatments for osteoporosis and other bone related diseases. Fucoxanthin is the main carotenoid found in brown seaweed, and has many perceived health benefits, including potential bone therapeutic properties. This study assessed the osteogenic potential of pure fucoxanthin and crude extracts containing both fucoxanthin and phenolic fractions (also cited to have osteogenic potential) isolated from two intertidal species of brown seaweed, Laminaria digitata and Ascophyllum nodosum. In vitro studies were performed using a human foetal osteoblast cell line (hFOBs) and primary human bone marrow stromal cells (hBMSCs). The results found pure fucoxanthin inhibitory to cell proliferation in hFOBs at higher concentrations, whereas, the crude extracts containing both polyphenols and fucoxanthin showed the ability to scavenge free radicals which masked this effect. None of the extracts tested showed strong pro-osteogenic effects in either cell type tested failing to support previously reported positive effects.

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    • The Osteogenic Potential of Brown Seaweed Extracts

      Rights statement: Copyright 2019 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.

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    DOI

    Original languageEnglish
    JournalMarine Drugs
    Journal publication date28 Feb 2019
    DOIs
    Publication statusPublished - 28 Feb 2019

    ID: 165397236