The Potential of Targeting DNA Repair Deficiency in Acute Myeloid Leukemia

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    Acute myeloid leukemia (AML) is a clonal heterogeneous disease of the myeloid white blood cells. It is characterised by an accumulation of immature blast cells and a number of chromosomal and genetic mutations have been identified. In both de novo and therapy-related AML, defective DNA repair mechanisms are responsible for some of these genetic abnormalities. Targeting the DNA repair mechanism has been shown to be successful against certain forms of solid tumors and may represent a novel therapeutic approach for AML

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    • The Potential of Targeting DNA Repair Deficiency in Acute Myeloid Leukemia

      Rights statement: © 2017 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.

      Final published version, 836 KB, PDF-document

    DOI

    Original languageEnglish
    Number of pages8
    Pages (from-to)691-698
    JournalJournal of Cancer Therapy
    Journal publication date28 Jul 2017
    Volume8
    DOIs
    Publication statusPublished - 28 Jul 2017

    ID: 133322063