The roles of TRIO and F-actin-binding protein in glioblastoma cells

    Research output: Contribution to journalArticle

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    • Hyunji Lee
    • Minhee Kim
    • Jisoo Park
    • Quangdon Tran
    • Youngeun Hong
    • Hyeonjeong Cho
    • Sungjin Park
    • Suntaek Hong
    • Derek P. Brazil
    • Seon Hwan Kim
    • Jongsun Park

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    TRIO and F-actin-binding protein (TrioBP), which was initially discovered as a binding partner of Trio and F-actin, is a critical factor associated with hearing loss in humans. However, the function of TrioBP in cancer has not been investigated. In the present study, TrioBP expression was indicated to be highly elevated in U87-MG and U343-MG cells. Furthermore, the TrioBP mRNA expression level was markedly increased in U87-MG and U251-MG cells compared with that in cerebral cortex cells, as determined by deep sequencing. Comprehensive analysis of a public TCGA dataset confirmed that TrioBP expression is elevated in patients with glioblastoma. In summary, the present data indicate that TrioBP expression is increased in glioblastoma cell lines and in patients with glioma, suggesting that TrioBP has potential as a diagnostic marker or therapeutic agent for glioma.

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    • The roles of TRIO and F-actin-binding protein in glioblastoma cells

      Rights statement: Copyright 2018 the authors. This is an open access article published under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.

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    DOI

    Original languageEnglish
    Number of pages7
    Pages (from-to)4540-4546
    JournalMolecular Medicine Reports
    Journal publication date01 Mar 2018
    Issue number3
    Volume17
    Early online date18 Jan 2018
    DOIs
    Publication statusPublished - 01 Mar 2018

      Research areas

    • Biomarker, Cytoskeleton, Glioma, TrioBP

    ID: 163620347